Does a woman need progesterone after menopause
Progesterone is a female sex hormone. Progesterone helps to regulate your cycle. But its main job is to get your uterus ready for pregnancy. After you ovulate each month, progesterone helps thicken the lining of the uterus to prepare for a fertilized egg. If there is no fertilized egg, progesterone levels drop and menstruation begins.
SEE VIDEO BY TOPIC: Skin and Hair Changes During MenopauseContent:
- Post-Menopause Brain Drain Tied to Progesterone
- Progesterone might relieve menopause symptoms
- Progesterone and the Nervous System/Brain
- When should a menopausal woman discontinue hormone therapy?
- Do Women Need Progesterone after a Hysterectomy?
- Progesterone-Alone for Hot Flashes and Night Sweats?
- 5 Experts Answer: Is Hormone Replacement Therapy Safe?
- Low Progesterone: Complications, Causes, and More
Post-Menopause Brain Drain Tied to Progesterone
In this emerging area of progesterone research, several research studies attest to the neuroprotective effects of progesterone, an absence of neurological side effects, and a benefit for cognitive function. Many women are familiar with progesterone as a hormone that is essential for fertility and for sustaining a pregnancy. By the time she reaches menopause, circulating progesterone levels are so low, they are similar to those normally seen in men. However, progesterone is far more than a gestational agent.
Research is now surfacing which shoes that the benefits of progesterone reach to breast health, cardiovascular health, and nervous system health, most importantly brain function. The rest of this article will take a closer look at just how essential progesterone is for your brain.
It is so essential that it comes from two different places to reach the brain: first, cells in the brain, spinal cord, and peripheral nervous system all synthesize progesterone from cholesterol. Secondly, progesterone that is circulating in the bloodstream also has direct access to the brain and nerves.
Normal brain function is not the only thing progesterone is required for in the nervous system. An important role of progesterone is to protect the brain from damage and promote repair after injury. It actually does this by promoting the growth and repair of the myelin sheath that protects the nerve fibers.
Around 20 years ago, researchers who were studying rats after brain injury made a significant observation. Female rats which, at the time of the brain injury, were at the stage of their reproductive cycles when progesterone levels were the highest, had significantly less brain damage than male rats or females with lower progesterone levels.
A review published this year suggests that not only should progesterone be used to treat traumatic brain injuries, but that it may also have a role in treating stroke, because of its powerful protective effects on brain tissue. This is a very exciting area of progesterone research, as researchers and clinicians acknowledge the fact that natural progesterone has an excellent safety profile without long term side effects, making it a good candidate for high dose therapy that can also be carried out in a home environment as patients recover.
There is published evidence that the children of women who were treated with progesterone during pregnancy showed enhanced development during infancy, achieved better academic results at ages , and were significantly more likely to attend universities. If progesterone levels are too low, normal brain development may be affected, putting an infant at a developmental disadvantage.
Progesterone naturally metabolizes in brain tissues to the metabolite allopregnanolone , which is known to produce calming, anti-anxiety and possibly enhanced memory effects. There is some speculation that it could be important in preserving cognitive function in women experiencing the decline in progesterone levels with age.
It will be interesting to see further research on this as aging women increasingly use progesterone in hormone replacement. Basically, there is a large quantity of metabolites produced in the liver after oral progesterone is absorbed by the intestines. These metabolites have known sedative and hypnotic effects. On the other hand, women using progesterone cream do not produce metabolites in such large quantities because the progesterone is absorbed through the skin and bypasses the liver metabolism.
Synthetic progestins are molecularly different from natural progesterone and therefore do not metabolize to the same compounds as natural progesterone.
They do not show benefits for cognitive or anti-anxiety function. The progestin that has been the most extensively studied and which is commonly used in synthetic hormone replacement therapy, MPA medroxyprogesterone acetate , has been found to have negative effects on the nervous system and even reduces the beneficial effects of estrogen.
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Our research database contains articles that are hand-picked to provide the most up-to-date and relevant information. Research Summary In this emerging area of progesterone research, several research studies attest to the neuroprotective effects of progesterone, an absence of neurological side effects, and a benefit for cognitive function. Progesterone and the brain By Margaret N.
Progesterone protects the brain from damage after traumatic brain injury Around 20 years ago, researchers who were studying rats after brain injury made a significant observation. Progesterone and brain development — smarter kids? Progesterone eases anxiety and facilitates memory Progesterone naturally metabolizes in brain tissues to the metabolite allopregnanolone , which is known to produce calming, anti-anxiety and possibly enhanced memory effects.
Progesterone as a sleeping aid? P rogestins vs. Progesterone: Same effects? First Name. Last Name. Email Address. Postal Code.
Progesterone might relieve menopause symptoms
Estrogen levels after menopause may have no impact on cognitive function, but progesterone levels might, researchers found. In an analysis of data from a prospective study, there were no significant associations between estrogen levels and cognition among postmenopausal women, Victor Henderson, MD , of Stanford University in Stanford, Calif. There was no relationship between the hormone and brain function whether women were newly postmenopausal, or if they'd been postmenopausal for at least 10 years. Progesterone, however, did appear to be related to verbal memory and global cognition among women who were newly postmenopausal, the researchers found.
Menopause is defined as the absence of menses for 1 year. Women usually experience menopause between 40 and 55 years of age, with the median age being Smokers and women with chronic illnesses tend to experience menopause at an earlier age Box 1. Menopause transition consists of fluctuating ovarian function and occurs 2 to 8 years before menopause and up to 1 year after the final menses.
Progesterone and the Nervous System/Brain
In this emerging area of progesterone research, several research studies attest to the neuroprotective effects of progesterone, an absence of neurological side effects, and a benefit for cognitive function. Many women are familiar with progesterone as a hormone that is essential for fertility and for sustaining a pregnancy. By the time she reaches menopause, circulating progesterone levels are so low, they are similar to those normally seen in men. However, progesterone is far more than a gestational agent. Research is now surfacing which shoes that the benefits of progesterone reach to breast health, cardiovascular health, and nervous system health, most importantly brain function. The rest of this article will take a closer look at just how essential progesterone is for your brain. It is so essential that it comes from two different places to reach the brain: first, cells in the brain, spinal cord, and peripheral nervous system all synthesize progesterone from cholesterol.
When should a menopausal woman discontinue hormone therapy?
JoAnn V. Pinkerton and Dr. James A. Simon provided peer review and comments for Dr. Kaunitz's case study.
This week, we asked gynecologists, endocrinologists and oncologists: Is hormone replacement therapy safe? Here's what they said. Flood-Shaffer, associate professor in the department of obstetrics and gynecology at the University of Cincinnati in Ohio:.
Do Women Need Progesterone after a Hysterectomy?
Estrogen thickens the lining of the uterus, preparing it for the possible implantation of a fertilized egg. Estrogen also influences how the body uses calcium, an important mineral in the building of bones. In addition, estrogen helps maintain healthy levels of cholesterol in the blood. Estrogen is necessary in keeping the vagina healthy.SEE VIDEO BY TOPIC: Considering Hormone Therapy – Mayo Clinic Women’s Health Clinic
Progesterone P4 helps balance estradiol E2 in the body, making its use in hormone replacement therapy HRT just as important as E2. Along with this idea, some believe that progesterone is unnecessary to supplement after women undergo a hysterectomy. While progesterone is known mostly for its effect on the uterus, P4 receptors are located in other parts of the body outside of the uterus as well, and have various effects on other tissues. Newer studies reveal additional effects of progesterone for bone health, hot flashes, and even sedation with implications for treatment of mood disorders. Progesterone may also be helpful for women who have undergone a hysterectomy. A study using progesterone cream applied on the skin daily for one year improved or resolved hot flashes significantly.
Progesterone-Alone for Hot Flashes and Night Sweats?
With 10 locations throughout NWA, we're always in your neighborhood. Visit us, order online or call: 1. To help relieve the symptoms of menopause, women are typically supplemented with estrogen therapy. For a woman who still has her uterus, estrogen therapy alone may cause the lining of the uterus to overgrow called hyperplasia and this can even lead to uterine cancer. To balance out this effect of estrogen, progesterone therapy is also given to these women. However, many experts claim that for a woman who has had a hysterectomy, she does not need progesterone therapy in her menopause treatment regimen because she no longer has a uterus and therefore cannot get uterine cancer.
Member Log In. The purpose of this joint statement is to demonstrate the experts do agree on the key points. The North American Menopause Society, the American Society for Reproductive Medicine, and The Endocrine Society take the position that most healthy, recently menopausal women can use hormone therapy for relief of their symptoms of hot flashes and vaginal dryness if they so choose. These medical organizations also agree that women should know the facts about hormone therapy. Below are the major points of agreement among these societies.
5 Experts Answer: Is Hormone Replacement Therapy Safe?
Hormone therapy was once routinely used to treat menopausal symptoms and protect long-term health. Then large clinical trials showed health risks. What does this mean for you?
Low Progesterone: Complications, Causes, and More
NEW YORK Reuters Health - A hormone called progesterone helps reduce how frequently and how severely women experience hot flashes and night sweats after menopause somewhat, according to a new study. Estrogen had been a popular hormone therapy to treat menopausal symptoms until some large studies raised concerns about a possible increased risk of stroke and cancer among women who were taking it see Reuters Health reports of October 19, and January 31, Progesterone has been used in hormone replacement therapy to treat menopausal symptoms, but it is typically thought of as an add-on to estrogen therapy to help protect the uterus from abnormal thickening.
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